Aging is one of the hottest topics today among men and women, young and old. As we forever chase the fountain of youth, it’s not surprising that we all want to know how to prepare ourselves for the battle ahead. One of … Continue reading
VANCOUVER, CANADA (April 16, 2012) – Glissandra Skincare, a product-driven MLM company with a strong international presence, invites its valued independent distributors and friends to celebrate the women who gave them life with these exclusive, limited-time offers.
Until Mother’s Day (May 13, 2012), active distributors who purchase one complete set of Glissandra’s 3-step skincare system (Glissandra Serum, Face Cream, and Eye Cream) will receive a special, one-time Mother’s Day bonus of 68 Incentive Dollars (IND), credited automatically to the purchasing distributor’s account. IND may be redeemed on eligible future purchases of Glissandra products.
In the same time period, new distributors will enjoy two special offers: 1) a reduced membership fee of just $1, and 2) the Mother’s Day Bonus of 68 IND, credited automatically to the purchasing distributor’s account, when they purchase the Quality Enroller Bonus package (Glissandra Serum, Face Cream, and Eye Cream) upon registration. The membership fee is regularly priced at US$30.
Glissandra Skincare always welcomes new distributors to join its growing team. Interested parties are encouraged to visit the company’s website, http://glissandra.com, for more information on this exciting opportunity.
About Glissandra™ Skincare Inc.
Glissandra™ Skincare Inc. is a network marketing company (also known as multi-level marketing, MLM, direct sales, or community commerce) dedicated to providing effective anti-aging skincare through its holistic approach to skin health. Glissandra’s comprehensive skincare system is the result of over 20 years of research and development at the Hong Kong University of Science and Technology, led by Professor Robert Ko, PhD (University of British Columbia). Over 100 research papers have been published on its proprietary key ingredient, Glissandrin™, a suite of natural compounds extracted from the Schisandra berry. In-vivo and in-vitro studies have proven the ability of Glissandrin™ to address mitochondrial decay, the leading cause of aging, and to enhance the cell’s natural ability to fight oxidative damage (http://glissandra.com).
Some time ago, we shared some information on protecting your skin from the elements using antioxidants. But as you know, not all antioxidants are created equal.
If you haven’t already heard about glutathione, here’s your quick primer on the extraordinary antioxidant that’s set to make waves in the skincare world in 2012.
Antioxidants as free radical fighters
As the cells in our body perform their everyday functions, they incidentally create free radicals. These byproducts accumulate over time and become progressively more detrimental to our health.
In the context of aging, we know that free radical damage is a significant contributor to unsightly skin issues such as wrinkles, dark under eye circles, and age spots.
This is where antioxidants come in. We can use these powerful molecules to offset the negative effects of free radicals. One way to do this is by consuming a diet that includes antioxidant-rich fruits and vegetables – but that’s not the only way, especially since this doesn’t directly target skin cells.
Glutathione: the master antioxidant
Our cells are also able to produce their own antioxidants. Because glutathione is widely considered to be the strongest, it is also known as the “master” antioxidant.
Glutathione detoxifies our body of toxins and pollutants, increases our energy, repairs DNA damage, and optimizes our immune system. Imagine how that power would positively affect our skin, the body’s largest organ.
The body produces glutathione naturally, but certain compounds have been scientifically proven to encourage our cells to produce more of it. This is an important concept to consider in regards to caring for our skin, particularly as we age, since our body accumulates free radicals over time.
Fortunately, there are now products on the market that are able to stimulate the body’s natural glutathione production. When applied directly to the skin, they are an effective way to reverse the signs of skin aging.
The role of glutathione in anti-aging skincare
Glutathione is the powerhouse antioxidant on which other antioxidants depend to function properly. Antioxidants commonly found in anti-aging skincare products, such as Vitamins C and E and CoQ10, are less effective without glutathione.
A recent study published in the scientific journal, Fitoterapia, showed that Schisandrin B increased glutathione production at the cellular level. This means that these powerful compounds are able to help our cells naturally produce more glutathione to attack free radicals.
Schisandrin B is derived from the Schisandra berry, an herb commonly used in traditional Chinese medicine (TCM). Extracts from the Schisandra berry have been proven to be safe and effective in topical cosmetic applications. In over two decades of research and development, Glissandra Skincare has identified and isolated the most potent compounds from the Schisandra berry for use in its advanced anti-aging skincare products.
Keep your skin looking young, healthy, and beautiful
Do your skincare products promote the health of your skin by stimulating skin cells to produce glutathione? Can you find Schisandrin B on the ingredient list of the products you’re currently using? If you’re constantly struggling to fight aging skin, consider how much more effective it would be if your body was able to do more on its own.
Glutathione is changing anti-aging skincare. By taking a holistic, health-focused approach to caring for our skin, beautiful, younger-looking skin is finally within our reach.
Chiu PY, PY Lam, Yan CW, Ko KM. Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts. Fitoterapia 2011; 82: 682-691.
Quirin, Dr. K. W. et al. Supercritical Schisandra Extracts – a New Concept for Personal Care Cosmetics. Cosmetic Science Technology, 2008.
Glissandrin™是首個得到生物科技驗證，有效減少歳月的痕跡，令肌膚呈現健康狀態的品牌。其成功的關鍵來自能保持皮膚青春的五味子嶄新成份。憑藉十七年的突破性研究， Glissandrin 揉合專利天然物與領先科技，針對肌膚衰老的根本原因 — 線粒體老化而出擊。此系列護膚三部曲如魔法般對付歳月痕跡，使肌膚回復年青。
This is Part 3 of a 3-part series on the quest by scientists to find effective ways to fight skin aging. In our previous article, entitled “What have scientists found to fight the leading cause of skin aging – mitochondrial decay?”, we discussed how Schisandrin B and (−)Schisandrin B have been proven to be successful in that regard, dramatically improving the appearance of aging skin.
A study related to this was recently published in the Journal of Cosmetic Dermatology, the official publication of the International Academy of Cosmetic Dermatology. “Mitochondria: a new focus as an anti-aging target in skin care” confirms the important role of mitochondrial function in aging and advocates targeting mitochondria in the development of new products.
Here, we continue to explore the use of Schisandrin B and (−)Schisandrin B in the revolutionary new ingredient, Glissandrin™, which promises to change the way we approach skin care.
As discussed in previous articles, mitochondrial decay plays a fundamental role in the process of aging. Over time, cells lose the ability to function normally, falling victim to free radicals and the ensuing oxidative stress. The consequences of this appear as the visible signs of skin aging, including wrinkles, fine lines, age spots, loss of suppleness, and a marked deterioration in skin tone.
Glissandrin™ is a suite of natural compounds isolated from the Schisandra berry. Consisting mainly of Schisandrin B and (−)Schisandrin B, Glissandrin™ also comprises (±)γ-Schisandrin, Schisandrin A, and Schisandrin C. Extensive research on Glissandrin™ has confirmed its anti-aging properties on skin cells, most notably on its ability to target the fundamental cause of aging: mitochondrial decay.
A. Mitochondrial decay in skin cells can be reversed by topical application of Glissandrin™
A 3-day application of Glissandrin™ cream (2% and 5%) to skin cells caused a dose-dependent increase in reduced glutathione (GSH) and α-tocopherol (α-Toc) levels in skin mitochondria. Glissandrin™ cream is able to enhance the antioxidant capacity of mitochondria and to reverse mitochondrial decay in aging skin cells.
Cream containing 2% or 5% Glissandrin™ was applied to skin cells on a daily basis for 3 days. The control group was treated with cream containing no Glissandrin™. Skin tissues were isolated and mitochondrial fractions were prepared. Mitochondrial reduced glutathione and α-tocopherol levels were measured. P < 0.05 when compared to the control, using Student’s t-test.
B. Mitochondrial functional capabilities in skin cells can be enhanced by topical application of Glissandrin™
Glissandrin™ also dose-dependently increased mitochondrial ATP (cellular energy) production in human skin cells, indicative of enhancement in mitochondrial functional ability.
Cultured human skin cells were incubated with Glissandrin™ at the indicated concentration for 24 or 48 hours. ATP generation capacity was measured in situ and data were expressed as the percentage of control. P < 0.05 when compared to the control, using Student’s t-test.
C. In-vivo and in-vitro studies have confirmed other properties of Glissandrin™ that are beneficial to the skin :
- Emolliating proliferative skin conditions
- Enhancing the natural antioxidative capabilities in skin cells
- Increasing the expression of cellular heat shock proteins, thereby alerting the skin to adverse external environmental factors
- Suppressing inflammation
- Inhibiting the production of collagenase, an enzyme that destroys collagen
- Protecting skin cells from solar radiation – particularly UV – and repairing skin cells with UV damage
- Reducing the destruction of elastin, a protein in the skin matrix responsible for skin elasticity
- Inhibiting ATR protein kinase activity (cancer prevention)
Glissandrin™ has been clinically tested to be safe for even the most sensitive skin, especially for users who experience adverse reactions to most skincare products.
The desired level of biological availability and the purity of chemical compositions of Glissandrin™ are standardized through a proprietary process developed specifically for its manufacturing. Furthermore, the concentrations of the constituent compounds have been formulated for easy absorption, optimal efficacy, and a luxurious feel when applied to the skin.
The International Academy of Cosmetic Dermatology has spoken, and its message is clear: targeting mitochondrial decay is now the goal of the anti-aging industry. Without understanding and addressing mitochondrial decay, the leading cause of skin aging, most skincare products are ill-equipped to provide the real, sustainable results they promise. Fortunately, Glissandrin™ is available today as the ultimate anti-aging skincare solution.
For More Information
More information on Schisandrin B, (−)Schisandrin B, and mitochondrial decay can be found on these independent websites:
National Institutes of Health (http://www.nih.gov/)
Natural Standard (http://www.naturalstandard.com/)
About Glissandra™ Skincare Inc.
Glissandra™ Skincare Inc. is a network marketing company (also known as multi-level marketing, MLM, or direct sales) dedicated to providing effective anti-aging skincare through its holistic approach to skin health. Glissandra’s comprehensive skincare system is the result of over 20 years of research and development at the Hong Kong University of Science and Technology, led by Dr. Robert Ko. Over 100 research papers have been published on its key proprietary ingredient, Glissandrin™, a suite of natural compounds extracted from the Schisandra berry. In-vivo and in-vitro studies have proven the ability of Glissandrin™ to address mitochondrial decay, the leading cause of aging, and to enhance the cell’s natural ability to fight oxidative damage. (http://glissandra.com).
“Mitochondria: a new focus as an anti-aging target in skin care”; Menon et al, Global R&D, ISP Corporation, New Jersey, USA; Journal of Cosmetic Dermatology 2010, Wiley Periodicals Inc.
“Composition and Biological Activity of Different Extract from Schisandra sphenanthera and Schisandra chinensis”; Huyke, et al., Department of Dermatology, University Medical Centre, Freiburg, Germany; Planta Medica 2007.
“Schisandrin B-induced increase in cellular glutathione level and protection against oxidant injury are mediated by the enhancement of glutathione synthesis and regeneration in AML12 and H9c2 cells”, Ko et al., Biofactors 2006; 26: 221-230.
“Hepatoprotective mechanism of Schisandrin B: Role of mitochondrial glutathione antioxidant status and heat shock proteins”, Ko et al., Free Radic. Biol. Med. 2003; 35: 368-380.
“Composition and Biological Activity of Different Extracts from Schisandra sphenanthera and Schisandra chinensis”, Huyke et al., Department of Dermatology, University Medical Center, Freiberg, Germany, Planta Med 2007 73: 1116-1126.
“Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts”; Ko et al.; Department of Biochemistry, the Hong Kong University of Science and Technology; Fitoterapia 82 (2011) 682-691.
“Inhibition of ATR protein kinase activity by Schisandrin B in DNA damage response”, H. Nishida et al., Department of Applied Life Science, Niigata University of Pharmacy and Applied Life Sciences; Nucleic Acids Research 2009, Vol. 37, No. 17.