A letter from a customer and fan

At our head office in Vancouver, Canada, the Glissandra team is always thrilled to receive letters, emails, and phone calls from enthusiastic customers – and sometimes their spouse! – who can’t wait to share the incredible experiences they’ve had since they were first introduced to Glissandra. It makes our day and reminds us of how lucky we are to be making a difference in people’s lives.
We don’t like to gloat, but we have some of the best customers and fans around! Take Pino, who splits his time between Vancouver and sunny California. He’s given us permission to share his unedited letter with you, in hopes of helping other people who have similar issues.
I had acute sunburn problems on my scalp for a long time, as I am Bald & enjoy exercising outdoor. I used to put on a lot of sun block, but that did not help with the development of redness with an expanded whitish colored skin, sometimes leading to blisters & scars. My skin was so delicate that only a light touch would generate a blister. Also my scalp had developed scalings.
Since using the Glissandra serum, my scalp has much improved. To ensure I have maximum protection I always put on an extra layer of serum just before doing sports under the sun (particularly in California where I spend quite a bit of time). I do not have blister problems anymore, and the scarred tissues are healed; even the pigmentation has improved greatly.
Thank you for sharing your story with us, Pino. We appreciate your support!

Beauty Buzzword: Glutathione

Some time ago, we shared some information on protecting your skin from the elements using antioxidants. But as you know, not all antioxidants are created equal.

If you haven’t already heard about glutathione, here’s your quick primer on the extraordinary antioxidant that’s set to make waves in the skincare world in 2012.

Antioxidants as free radical fighters

As the cells in our body perform their everyday functions, they incidentally create free radicals. These byproducts accumulate over time and become progressively more detrimental to our health.

In the context of aging, we know that free radical damage is a significant contributor to unsightly skin issues such as wrinkles, dark under eye circles, and age spots.

This is where antioxidants come in. We can use these powerful molecules to offset the negative effects of free radicals. One way to do this is by consuming a diet that includes antioxidant-rich fruits and vegetables – but that’s not the only way, especially since this doesn’t directly target skin cells.

Glutathione: the master antioxidant

Our cells are also able to produce their own antioxidants. Because glutathione is widely considered to be the strongest, it is also known as the “master” antioxidant.

Glutathione detoxifies our body of toxins and pollutants, increases our energy, repairs DNA damage, and optimizes our immune system. Imagine how that power would positively affect our skin, the body’s largest organ.

The body produces glutathione naturally, but certain compounds have been scientifically proven to encourage our cells to produce more of it. This is an important concept to consider in regards to caring for our skin, particularly as we age, since our body accumulates free radicals over time.

Fortunately, there are now products on the market that are able to stimulate the body’s natural glutathione production. When applied directly to the skin, they are an effective way to reverse the signs of skin aging.

The role of glutathione in anti-aging skincare

Glutathione is the powerhouse antioxidant on which other antioxidants depend to function properly. Antioxidants commonly found in anti-aging skincare products, such as Vitamins C and E and CoQ10, are less effective without glutathione.

A recent study published in the scientific journal, Fitoterapia, showed that Schisandrin B increased glutathione production at the cellular level. This means that these powerful compounds are able to help our cells naturally produce more glutathione to attack free radicals.

Schisandrin B is derived from the Schisandra berry, an herb commonly used in traditional Chinese medicine (TCM). Extracts from the Schisandra berry have been proven to be safe and effective in topical cosmetic applications. In over two decades of research and development, Glissandra Skincare has identified and isolated the most potent compounds from the Schisandra berry for use in its advanced anti-aging skincare products.

Keep your skin looking young, healthy, and beautiful

Do your skincare products promote the health of your skin by stimulating skin cells to produce glutathione? Can you find Schisandrin B on the ingredient list of the products you’re currently using? If you’re constantly struggling to fight aging skin, consider how much more effective it would be if your body was able to do more on its own.

Glutathione is changing anti-aging skincare. By taking a holistic, health-focused approach to caring for our skin, beautiful, younger-looking skin is finally within our reach.

References

Chiu PY, PY Lam, Yan CW, Ko KM. Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts. Fitoterapia 2011; 82: 682-691.

Quirin, Dr. K. W. et al. Supercritical Schisandra Extracts – a New Concept for Personal Care Cosmetics. Cosmetic Science Technology, 2008.

Celebrate Valentine’s Day With TWO Special Bonus Offers from Glissandra 姿羨 情人節酬賓優惠

February is the perfect time to celebrate the ones you love – including you! And since the eyes are the window to your soul, here are a couple of special Valentine’s treats for your peepers.

1. Until Valentine’s Day, when you purchase our complete Glissandra Skincare system (Serum, Face Cream, and Eye Cream), we’ll send you a bonus, full-size Eye Cream (retail value of $88US), and…

2. When you sponsor a new member who purchases a Quality Enroller Bonus (QEB) package at sign up, both the sponsor and the new member will EACH receive a bonus, full-size Eye Cream (retail value of $88US).

Show yourself some love with our rejuvenating Eye Cream, packed with a trio of potent ingredients – Glissandrin(TM), Eyeliss(TM), and Haloxyl(TM) – to reduce under eye circles, calm puffiness, and erase fine lines. Or share it with your loved ones!

Place your order today. This offer is valid from February 1, 2012 – February 14, 2012, while quantities last.

本公司從今天起 , 到 2 月 14 日止 , 慶祝情人節酬賓活動 :

1. 凡會員購買一套產品 ( 精華素 + 臉霜 + 眼霜 ), 會獲贈眼霜一盒 .

2. 凡推薦新會員加入 , 而該新會員購買一套 ”優質會員迎新套裝” (QEB) , 新會員和推薦人都會獲贈眼霜一盒 .

Glissandra Eye Cream

Glissandrin™: The Ultimate Anti-Aging Skincare Ingredient

This is Part 3 of a 3-part series on the quest by scientists to find effective ways to fight skin aging. In our previous article, entitled “What have scientists found to fight the leading cause of skin aging – mitochondrial decay?”, we discussed how Schisandrin B and (−)Schisandrin B have been proven to be successful in that regard, dramatically improving the appearance of aging skin.

A study related to this was recently published in the Journal of Cosmetic Dermatology, the official publication of the International Academy of Cosmetic Dermatology. “Mitochondria: a new focus as an anti-aging target in skin care” confirms the important role of mitochondrial function in aging and advocates targeting mitochondria in the development of new products.

Here, we continue to explore the use of Schisandrin B and (−)Schisandrin B in the revolutionary new ingredient, Glissandrin™, which promises to change the way we approach skin care.

As discussed in previous articles, mitochondrial decay plays a fundamental role in the process of aging. Over time, cells lose the ability to function normally, falling victim to free radicals and the ensuing oxidative stress. The consequences of this appear as the visible signs of skin aging, including wrinkles, fine lines, age spots, loss of suppleness, and a marked deterioration in skin tone.

Glissandrin™

Glissandrin™ is a suite of natural compounds isolated from the Schisandra berry. Consisting mainly of Schisandrin B and (−)Schisandrin B, Glissandrin™ also comprises (±)γ-Schisandrin, Schisandrin A, and Schisandrin C. Extensive research on Glissandrin™ has confirmed its anti-aging properties on skin cells, most notably on its ability to target the fundamental cause of aging: mitochondrial decay.

Research Findings

A. Mitochondrial decay in skin cells can be reversed by topical application of Glissandrin™

A 3-day application of Glissandrin™ cream (2% and 5%) to skin cells caused a dose-dependent increase in reduced glutathione (GSH) and α-tocopherol (α-Toc) levels in skin mitochondria. Glissandrin™ cream is able to enhance the antioxidant capacity of mitochondria and to reverse mitochondrial decay in aging skin cells.

Figure 1: Glissandrin™ enhances mitochondrial antioxidant capacity in the skin

Cream containing 2% or 5% Glissandrin™ was applied to skin cells on a daily basis for 3 days. The control group was treated with cream containing no Glissandrin™. Skin tissues were isolated and mitochondrial fractions were prepared. Mitochondrial reduced glutathione and α-tocopherol levels were measured. P < 0.05 when compared to the control, using Student’s t-test.

B. Mitochondrial functional capabilities in skin cells can be enhanced by topical application of Glissandrin™

Glissandrin™ also dose-dependently increased mitochondrial ATP (cellular energy) production in human skin cells, indicative of enhancement in mitochondrial functional ability.

Figure 2: Glissandrin™ enhances the mitochondrial functional ability in human skin cells

Cultured human skin cells were incubated with Glissandrin™ at the indicated concentration for 24 or 48 hours. ATP generation capacity was measured in situ and data were expressed as the percentage of control. P < 0.05 when compared to the control, using Student’s t-test.

C. In-vivo and in-vitro studies have confirmed other properties of Glissandrin™ that are beneficial to the skin :

  • Emolliating proliferative skin conditions
  • Enhancing the natural antioxidative capabilities in skin cells
  • Increasing the expression of cellular heat shock proteins, thereby alerting the skin to adverse external environmental factors
  • Suppressing inflammation
  • Inhibiting the production of collagenase, an enzyme that destroys collagen
  • Protecting skin cells from solar radiation – particularly UV – and repairing skin cells with UV damage
  • Reducing the destruction of elastin, a protein in the skin matrix responsible for skin elasticity
  • Inhibiting ATR protein kinase activity (cancer prevention)

Glissandrin™ has been clinically tested to be safe for even the most sensitive skin, especially for users who experience adverse reactions to most skincare products.

The desired level of biological availability and the purity of chemical compositions of Glissandrin™ are standardized through a proprietary process developed specifically for its manufacturing. Furthermore, the concentrations of the constituent compounds have been formulated for easy absorption, optimal efficacy, and a luxurious feel when applied to the skin.

The International Academy of Cosmetic Dermatology has spoken, and its message is clear: targeting mitochondrial decay is now the goal of the anti-aging industry. Without understanding and addressing mitochondrial decay, the leading cause of skin aging, most skincare products are ill-equipped to provide the real, sustainable results they promise. Fortunately, Glissandrin™ is available today as the ultimate anti-aging skincare solution.

For More Information

More information on Schisandrin B, (−)Schisandrin B, and mitochondrial decay can be found on these independent websites:

National Institutes of Health (http://www.nih.gov/)

PubMed (http://www.ncbi.nlm.nih.gov/pubmed/)

Natural Standard (http://www.naturalstandard.com/)

About Glissandra™ Skincare Inc.

Glissandra™ Skincare Inc. is a network marketing company (also known as multi-level marketing, MLM, or direct sales) dedicated to providing effective anti-aging skincare through its holistic approach to skin health. Glissandra’s comprehensive skincare system is the result of over 20 years of research and development at the Hong Kong University of Science and Technology, led by Dr. Robert Ko. Over 100 research papers have been published on its key proprietary ingredient, Glissandrin™, a suite of natural compounds extracted from the Schisandra berry. In-vivo and in-vitro studies have proven the ability of Glissandrin™ to address mitochondrial decay, the leading cause of aging, and to enhance the cell’s natural ability to fight oxidative damage. (http://glissandra.com).

Contact Us

http://www.glissandra.com/

info [at] glissandra [dot] com

1-877-313-7242

References

“Mitochondria: a new focus as an anti-aging target in skin care”; Menon et al, Global R&D, ISP Corporation, New Jersey, USA; Journal of Cosmetic Dermatology 2010, Wiley Periodicals Inc.

“Composition and Biological Activity of Different Extract from Schisandra sphenanthera and Schisandra chinensis”; Huyke, et al., Department of Dermatology, University Medical Centre, Freiburg, Germany; Planta Medica 2007.

“Schisandrin B-induced increase in cellular glutathione level and protection against oxidant injury are mediated by the enhancement of glutathione synthesis and regeneration in AML12 and H9c2 cells”, Ko et al., Biofactors 2006; 26: 221-230.

“Hepatoprotective mechanism of Schisandrin B: Role of mitochondrial glutathione antioxidant status and heat shock proteins”, Ko et al., Free Radic. Biol. Med. 2003; 35: 368-380.

“Composition and Biological Activity of Different Extracts from Schisandra sphenanthera and Schisandra chinensis”, Huyke et al., Department of Dermatology, University Medical Center, Freiberg, Germany, Planta Med 2007 73: 1116-1126.

“Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts”; Ko et al.; Department of Biochemistry, the Hong Kong University of Science and Technology; Fitoterapia 82 (2011) 682-691.

“Inhibition of ATR protein kinase activity by Schisandrin B in DNA damage response”, H. Nishida et al., Department of Applied Life Science, Niigata University of Pharmacy and Applied Life Sciences; Nucleic Acids Research 2009, Vol. 37, No. 17.

Schisandrin B: Ushering in a New Era in UV Protective Skincare

Introduction

Schisandrin B, a key component of Glissandrin, can protect against solar irradiation-induced oxidative injury in skin tissue and skin cells, according to recent research findings from the laboratory of Dr. Robert Ko at the Hong Kong University of Science and Technology.

As the largest organ in the human body, the skin serves as an effective barrier for protecting against various external threats. This includes exposure to harmful solar irradiation – particularly UV and infrared rays – which research has shown to be a major cause of skin aging. Solar irradiation-induced reactive oxygen species (ROS) generation is responsible for photo-aging, the signs of which include wrinkles, coarse skin texture, and reduced skin resilience. Although human skin tissue possesses non-enzymatic and enzymatic antioxidant defense systems to cope with the increased oxidative stress caused by solar light radiation, long-term exposure or over-exposure to solar light can overwhelm the antioxidant system.

But what if there was a way to enhance the skin’s natural antioxidant defenses to prevent photo-aging entirely? Schisandrin B (Sch B) is able to do just that, ushering in a new era in UV protective skincare.

Schisandrin B is derived from the Schisandra fruit, an herb commonly used in Traditional Chinese Medicine (TCM). This naturally occurring herbal ingredient has been found to produce tissue non-specific protection against oxidative injury by enhancing cellular and mitochondrial glutathione antioxidant status in the heart, liver, kidney, and brain.

Figure 1: Schisandra berry

Recent studies led by Dr. Robert Ko at the Hong Kong University of Science and Technology have shown the promise of Schisandrin B:

• Schisandrin B stimulated both reduced-glutathione and vitamin E levels. These two non-enzymatic antioxidants can remove excess ROS during oxidative stress in a synergistic manner.
• Schisandrin B elevated various enzymes involved in the enzymatic antioxidant defense system, demonstrating that non-enzymatic and enzymatic antioxidant components work together to protect against solar irradiation-induced oxidative injury in skin tissue.

Figure 2: Effects of Sch B pretreatment on solar irradiation-induced cell injury in BJ human fibroblasts

• Schisandrin B suppressed the solar irradiation-induced increases in elastases-type protease activity and matrix-metalloproteinases-1 (MMP-1) expression in skin cells. The degradation of the extracellular matrix (EM) in skin tissue as a result of solar irradiation is of prime concern in skincare. This is one of the major biological events that leads to photo-aging and is mediated by protein-degrading enzymes like elastases-type protease and MMP-1.

Figure 3: Effects of Sch B pretreatment on cellular elastases-type protease activity in solar-irradiated BJ human fibroblasts

Figure 4: Effects of Sch B pretreatment on cellular MMP-1 level in solar-irradiated BJ human fibroblasts

Schisandrin B is a key component of Glissandrin™, a potent anti-aging skincare ingredient that has been the subject of over 100 research papers. In-vivo and in-vitro studies have proven the ability of Glissandrin to reverse mitochondrial decay , the leading cause of aging, and to simultaneously enhance the cell’s natural ability to fight oxidative damage.

Other studies have shown the ability of Schisandrin B to suppress collagenase, an enzyme responsible for the depletion of collagen in skin cells. Research has also been conducted on the compound’s anti-cancer properties, particularly in the skin.

Figure 5: Mitochondria

Conclusion

Given that both spectra of solar light – UV and infrared radiation – are major causes of skin aging, Schisandrin B’s ability to enhance the skin’s antioxidant defenses against harmful solar irradiation, thereby offering the prospect of preventing skin photo-aging, is instigating a new era in skincare.

For more information

More information on Schisandrin B, mitochondrial decay, and theories of aging can be found at these independent websites:

• National Institutes of Health (http://www.nih.gov/)
• PubMed (http://www.ncbi.nlm.nih.gov/pubmed/)
• Natural Standard (http://www.naturalstandard.com/)

Background and References

Schisandrin B is a key component of Glissandrin™, the proprietary ingredient in Glissandra™ products.

Dr. Robert Ko holds a PhD from the University of British Columbia in Vancouver, Canada. He is currently a Professor in the Division of Life Science at the Hong Kong University of Science and Technology, and Chief Technology Officer of Glissandra Skincare Inc.

The Hong Kong University of Science and Technology is ranked 41st among research universities worldwide by Times Higher Education 2010 (London, UK).

Lam PY, Leong PK, Chen N, Ko KM: Schisandrin B enhances the glutathione redox cycling and protects against oxidant injury in different types of cultured cells. Biofactors (in press).

Chiu, P.Y., and Ko, K.M. (2006). Schisandrin B-induced increase in cellular glutathione level and protection against oxidant injury are mediated by the enhancement of glutathione synthesis and regeneration in AML12 and H9c2 cells. Biofactors 26: 221-230.

Chiu, P.Y., Leung, H.Y., and Ko, K.M. (2008). Schisandrin B enhances renal mitochondrial antioxidant status, functional and structural integrity, and protects against gentamicin-induced nephrotoxicity in rats. Biol. Pharm. Bull. 31: 602-605.

Chen, N., Chiu, P.Y., and Ko, K.M. (2008). Schisandrin B enhances cerebral mitochondrial antioxidant status and structural integrity, and protects against cerebral ischemia/reperfusion injury in rats. Biol. Pharm. Bull. 31: 1387-1391.

Lam PY, Yan CW, Chiu PY, Leung HY, Ko KM. Schisandrin B protects against solar irradiation-induced oxidative stress in rat skin tissue. Fitoterapia 2011; 82: 393-400.

Chiu PY, PY Lam, Yan CW, Ko KM. Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts. Fitoterapia 2011; 82: 682-691.

Nisida H, Tatewaki N, Magara T, Nakajima Y, Ko KM, Hamamori Y, Konishi T: Inhibition of ATR kinase activity by schisandrin B in DNA damage response. Nucleic Acid Res. 2009; 37: 5678-5689.