Aging is one of the hottest topics today among men and women, young and old. As we forever chase the fountain of youth, it’s not surprising that we all want to know how to prepare ourselves for the battle ahead. One of … Continue reading
Half a century ago, a German dermatologist concocted an ointment to treat skin that had undergone harsh cosmetic procedures. Dubbed a “blemish balm” or “BB cream”, the creation gained popularity in Asia, with Korean customers leading the way.
Now, BB creams are all the rage in North American, as major brands launch their own version of the multi-tasking hybrid that aims to bridge the gap between skincare and cosmetics.
It’s hard to believe that any product can replace all the steps in your skincare routine without compromising the effectiveness of each. But when we compare the claims made by BB creams with the proven benefits of the Glissandra Serum, it’s clear that Glissandra has been developing its own interpretation of a BB cream in the decades of research behind its potent Serum.
Glissandra Serum is powered by Glissandrin™, a patented suite of health-promoting compounds extracted from the Schisandra berry. This youth-preserving fruit has been the foundation of thousands of years of traditional Chinese medicine, and its potent extracts are now the subject of intensive study in Western medicine, as scientists search for a sustainable way to maintain the function of the body’s organs as we age.
Let’s take a look at how the Glissandra Serum, with Glissandrin at its core, stacks up against BB creams.
|BB Cream||Glissandra Serum|
|Smooth skin after cosmetic treatments||
|Moisturize the skin||
|Protect from the sun||
|Even skin tone and hide blemishes||
Healthy, young-looking skin is now within reach; we simply need to shift the focus from covering skin to creating naturally beautiful skin at the cellular level; from fighting symptoms to addressing the root cause of skin issues, mitochondrial decay. Before jumping on the BB cream bandwagon, consider how you can achieve real, sustainable results from products that put skin health first.
In a recent post, we learned that Schisandrin B stimulates the production of glutathione (GSH), the body’s most potent natural antioxidant. Using anti-aging skincare products that contain Schisandrin B will effectively and drastically reduce the unsightly physical manifestations of skin aging, such as wrinkles, age spots, droopy eyelids, and sagging neck skin.
Like no man is an island, no organ of the body functions entirely independently of the others. Our cells work in harmony to create and sustain life. Though we have discussed the importance of glutathione in skin health, it is important to consider the wider-ranging implications of glutathione for our overall well-being.
Here’s what some of the experts are saying about the role of glutathione in health:
“No other antioxidant is as important to overall health as glutathione. It is the regenerator of immune cells and the most valuable detoxifying agent in the body. Low levels are associated with early aging and even death.”
– Lorna R. Vanderhaeghe and Patrick J.D. Bouic, Ph.D., The Immune System Cure
“Raised glutathione levels fight the oxidation of circulating fats in the bloodstream, including cholesterol, retarding the process of plaque formation in the arteries – the underlying cause for most heart disease and stroke.”
– Nutrition Reviews 54: 1-30, 1996
“It is well known that aging is accompanied by a precipitous fall in GSH levels. Lower GSH levels are implicated in many diseases associated with aging, including cataracts, Alzheimer’s disease, Parkinson’s, atherosclerosis and others.”
– Journal of Clinical Epidemiology 47: 1021-26, 1994
The future of healthy aging
Scientists around the world have been pursuing progressively more advanced research on glutathione and Schisandrin B. We may not be able to stop the clock, but what we already know about these compounds demonstrates their significance in the campaign for healthy aging, starting with the body’s largest organ: our skin.
Quirin, Dr. K. W. et al. Supercritical Schisandra Extracts – a New Concept for Personal Care Cosmetics. Cosmetic Science Technology, 2008.
Gutman, Dr. Jimmy. GSH Your Body’s Most Powerful Protector GLUTATHIONE. Montreal: Kudo.ca Communications, 2002. Print.
Somersall, Dr. Allan C. and Dr. Gustavo Bounous. Breakthrough in Cell-Defense. USA: GOLDENeight Publishing, 1999. Print.
Vanderhaeghe, Lorna R. and Patrick J.D. Bouic, Ph.D. The Immune System Cure. New York: Kensington, 2002. Print.
This is Part 3 of a 3-part series on the quest by scientists to find effective ways to fight skin aging. In our previous article, entitled “What have scientists found to fight the leading cause of skin aging – mitochondrial decay?”, we discussed how Schisandrin B and (−)Schisandrin B have been proven to be successful in that regard, dramatically improving the appearance of aging skin.
A study related to this was recently published in the Journal of Cosmetic Dermatology, the official publication of the International Academy of Cosmetic Dermatology. “Mitochondria: a new focus as an anti-aging target in skin care” confirms the important role of mitochondrial function in aging and advocates targeting mitochondria in the development of new products.
Here, we continue to explore the use of Schisandrin B and (−)Schisandrin B in the revolutionary new ingredient, Glissandrin™, which promises to change the way we approach skin care.
As discussed in previous articles, mitochondrial decay plays a fundamental role in the process of aging. Over time, cells lose the ability to function normally, falling victim to free radicals and the ensuing oxidative stress. The consequences of this appear as the visible signs of skin aging, including wrinkles, fine lines, age spots, loss of suppleness, and a marked deterioration in skin tone.
Glissandrin™ is a suite of natural compounds isolated from the Schisandra berry. Consisting mainly of Schisandrin B and (−)Schisandrin B, Glissandrin™ also comprises (±)γ-Schisandrin, Schisandrin A, and Schisandrin C. Extensive research on Glissandrin™ has confirmed its anti-aging properties on skin cells, most notably on its ability to target the fundamental cause of aging: mitochondrial decay.
A. Mitochondrial decay in skin cells can be reversed by topical application of Glissandrin™
A 3-day application of Glissandrin™ cream (2% and 5%) to skin cells caused a dose-dependent increase in reduced glutathione (GSH) and α-tocopherol (α-Toc) levels in skin mitochondria. Glissandrin™ cream is able to enhance the antioxidant capacity of mitochondria and to reverse mitochondrial decay in aging skin cells.
Cream containing 2% or 5% Glissandrin™ was applied to skin cells on a daily basis for 3 days. The control group was treated with cream containing no Glissandrin™. Skin tissues were isolated and mitochondrial fractions were prepared. Mitochondrial reduced glutathione and α-tocopherol levels were measured. P < 0.05 when compared to the control, using Student’s t-test.
B. Mitochondrial functional capabilities in skin cells can be enhanced by topical application of Glissandrin™
Glissandrin™ also dose-dependently increased mitochondrial ATP (cellular energy) production in human skin cells, indicative of enhancement in mitochondrial functional ability.
Cultured human skin cells were incubated with Glissandrin™ at the indicated concentration for 24 or 48 hours. ATP generation capacity was measured in situ and data were expressed as the percentage of control. P < 0.05 when compared to the control, using Student’s t-test.
C. In-vivo and in-vitro studies have confirmed other properties of Glissandrin™ that are beneficial to the skin :
- Emolliating proliferative skin conditions
- Enhancing the natural antioxidative capabilities in skin cells
- Increasing the expression of cellular heat shock proteins, thereby alerting the skin to adverse external environmental factors
- Suppressing inflammation
- Inhibiting the production of collagenase, an enzyme that destroys collagen
- Protecting skin cells from solar radiation – particularly UV – and repairing skin cells with UV damage
- Reducing the destruction of elastin, a protein in the skin matrix responsible for skin elasticity
- Inhibiting ATR protein kinase activity (cancer prevention)
Glissandrin™ has been clinically tested to be safe for even the most sensitive skin, especially for users who experience adverse reactions to most skincare products.
The desired level of biological availability and the purity of chemical compositions of Glissandrin™ are standardized through a proprietary process developed specifically for its manufacturing. Furthermore, the concentrations of the constituent compounds have been formulated for easy absorption, optimal efficacy, and a luxurious feel when applied to the skin.
The International Academy of Cosmetic Dermatology has spoken, and its message is clear: targeting mitochondrial decay is now the goal of the anti-aging industry. Without understanding and addressing mitochondrial decay, the leading cause of skin aging, most skincare products are ill-equipped to provide the real, sustainable results they promise. Fortunately, Glissandrin™ is available today as the ultimate anti-aging skincare solution.
For More Information
More information on Schisandrin B, (−)Schisandrin B, and mitochondrial decay can be found on these independent websites:
National Institutes of Health (http://www.nih.gov/)
Natural Standard (http://www.naturalstandard.com/)
About Glissandra™ Skincare Inc.
Glissandra™ Skincare Inc. is a network marketing company (also known as multi-level marketing, MLM, or direct sales) dedicated to providing effective anti-aging skincare through its holistic approach to skin health. Glissandra’s comprehensive skincare system is the result of over 20 years of research and development at the Hong Kong University of Science and Technology, led by Dr. Robert Ko. Over 100 research papers have been published on its key proprietary ingredient, Glissandrin™, a suite of natural compounds extracted from the Schisandra berry. In-vivo and in-vitro studies have proven the ability of Glissandrin™ to address mitochondrial decay, the leading cause of aging, and to enhance the cell’s natural ability to fight oxidative damage. (http://glissandra.com).
“Mitochondria: a new focus as an anti-aging target in skin care”; Menon et al, Global R&D, ISP Corporation, New Jersey, USA; Journal of Cosmetic Dermatology 2010, Wiley Periodicals Inc.
“Composition and Biological Activity of Different Extract from Schisandra sphenanthera and Schisandra chinensis”; Huyke, et al., Department of Dermatology, University Medical Centre, Freiburg, Germany; Planta Medica 2007.
“Schisandrin B-induced increase in cellular glutathione level and protection against oxidant injury are mediated by the enhancement of glutathione synthesis and regeneration in AML12 and H9c2 cells”, Ko et al., Biofactors 2006; 26: 221-230.
“Hepatoprotective mechanism of Schisandrin B: Role of mitochondrial glutathione antioxidant status and heat shock proteins”, Ko et al., Free Radic. Biol. Med. 2003; 35: 368-380.
“Composition and Biological Activity of Different Extracts from Schisandra sphenanthera and Schisandra chinensis”, Huyke et al., Department of Dermatology, University Medical Center, Freiberg, Germany, Planta Med 2007 73: 1116-1126.
“Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts”; Ko et al.; Department of Biochemistry, the Hong Kong University of Science and Technology; Fitoterapia 82 (2011) 682-691.
“Inhibition of ATR protein kinase activity by Schisandrin B in DNA damage response”, H. Nishida et al., Department of Applied Life Science, Niigata University of Pharmacy and Applied Life Sciences; Nucleic Acids Research 2009, Vol. 37, No. 17.