Glissandra Skincare Proudly Supports World Figure Skating Champion, Patrick Chan

On Saturday, February 18, 2012, hundreds of guests packed the Victoria Chinese Restaurant in Downtown Vancouver to celebrate Canadian figure skater, Patrick Chan. The event was hosted by the World Chinese Business Association of Canada and raised almost $60,000 to assist in Chan’s training as he sets his sights on a gold medal in men’s figure skating at the 2014 Winter Olympics in Sochi, Russia. Glissandra Skincare donated its groundbreaking anti-aging skincare products to the event’s silent auction. Representatives of the company were also in attendance at the fundraiser to show their support.

As the winner of the last five major world championships, Chan has captured the hearts of Canadians and figure skating enthusiasts from around the world. Like Chan, Glissandra Skincare is dedicated to setting a new standard of excellence on the international stage.

Independent Glissandra distributor, Julie Jang, will generously donate $50 to Patrick Chan’s training fund for each new, personally sponsored member that purchases a complete set of Glissandra’s principal products – Serum, Face Cream, and Eye Cream – and mentions Patrick Chan’s recent victory at the Four Continents figure skating championship in Colorado Springs, Colorado. Glissandra Skincare will also send one bonus, full-size Eye Cream to these qualifying new members as a welcome gift. This offer is valid, while quantities last, until March 31, 2012.

Glissandra Skincare is a health-focused skincare company whose advanced anti-aging products are available through its international network of independent distributors. Its products are powered by Glissandrin™, a patented suite of potent natural compounds scientifically proven to enhance the cell’s natural antioxidative capabilities and to target mitochondrial decay, the fundamental cause of aging. The products have been clinically tested for safety and effectiveness in addressing all visible signs of skin aging holistically, particularly for users with sensitive skin.

Glissandra Skincare welcomes new distributors to join its growing team. Interested parties are encouraged to visit the company’s website, http://glissandra.com, for more information on this exciting opportunity.

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What have scientists found to fight the leading cause of skin aging – mitochondrial decay?

Introduction

This is Part 2 of a 3-part series on the quest by scientists to find effective ways to fight skin aging. In our previous article, entitled “What causes skin aging: Making sense of the latest research findings”, we discussed how oxidative damage is regarded in the scientific community as the primary cause of aging, and how mitochondria play a significant role in this by being a major source of free radicals.

Now, scientists have made a breakthrough in fighting the leading cause of skin aging: Schisandrins have been proven to effectively reverse mitochondrial decay.

A recap of our previous discussion

Mitochondrial decay in aging refers to a progressive disruption to mitochondrial structural integrity and functional ability over time. Consequently, cells experience impaired energy production, a decline in normal function, and accelerated free radical generation. This is the phenomenon of cellular aging, which makes the cell more prone to apoptosis, or programmed cell death – much like cell suicide.

Figure 1: Structure of a mitochondrion

Skin aging – the signs of which are commonly manifested in wrinkles, fine lines, age spots, loss of suppleness, and deterioration of skin tone – has been proven to involve mitochondrial dysfunction.

The mitochondria–free radical connection

Research has shown that mitochondria are a major source of free radicals. Deteriorating mitochondria instigate a vicious cycle of exacerbated oxidative stress. Consistent with these findings is the concept that “manipulating the signaling pathways that regulate cellular antioxidant defense” and “controlling the intracellular levels of free radicals” is preferred over “altering individual antioxidant components by extrinsic supplementation”.

In simpler terms, this means that it may be more effective to combat aging by treating the source of free radical production rather than by “cleaning up” free radicals after they are generated. This theory is supported by recent studies that have found that scavenging free radicals through the supplementation of certain antioxidants could be ineffective or even harmful in the long run.[i] [ii]

The role of Schisandrin B in skin-related mitochondrial decay

There has been a substantial amount of research on remedies to combat mitochondrial decay as an effective means of mitigating the aging process. Particularly noteworthy is the research conducted by Dr. Bruce Ames (UC Berkeley) and Dr. Tory Hagen (Oregon State University), who investigated the effects of acetyl-L-carnitine and alpha-lipoic acid on improving the functional capability of mitochondria.

Over the past few decades, the pharmacological activities of Schisandrin B, an active ingredient isolated from Fructus Schisandrae (commonly known as the Schisandra berry), have been studied extensively. Research conducted at RK-Lab at the Hong Kong University of Science and Technology have demonstrated the protective effect of Schisandrin B on free radical-induced damage in various vital organs, including the heart, liver, kidney, and brain.

Figure 2: Fresh Schisandra berries

Research has shown that Schisandrin B is able to simultaneously:

  1. enhance mitochondrial functional ability, and
  2. increase natural mitochondrial antioxidant capacity.

These are clear indications that this natural compound is effective in mitigating further mitochondrial decay, successfully defeating this leading cause of skin aging.

In addition, Schisandrin B has been proven to be able to induce the expression of heat shock proteins, endogenous protein molecules essential in cellular protection against various stressful stimuli. The expression of heat shock proteins is believed by many in the scientific community to be another crucial biochemical mechanism for fighting aging.

The latest research

Recent research has found a stereoisomer of Schisandrin B, (−)Schisandrin B, to be even more potent in enhancing mitochondrial functional ability and in boosting the innate antioxidant capacity of mitochondria.

Figure 3: Comparison of a cell treated with (−)Schisandrin B vs. a cell with no treatment

(−)Schisandrin B protects cells against oxidative stress, thereby preventing disease and enabling a healthier and longer lifespan.  Without (−)Schisandrin B, cells are vulnerable to oxidative stress. This results in the loss of structural and functional integrity and cyto c release, and ultimately leads to cell death.

Implications for anti-aging skincare

The pharmacological properties of Schisandrin B and (−)Schisandrin B have significant implications for anti-aging skincare, since skin is the largest organ of the human body, and oxidative damage has been recognized as one of the major factors that contribute to skin aging. Wrinkles, fine line, age spots, sagginess, loss of radiance, and many other signs of skin aging are all attributed to oxidative damage.

Studies at RK-Lab at the Hong Kong University of Science and Technology[iii] have validated the beneficial effects of Schisandrin B and (−)Schisandrin B on skin cells and skin tissues. Furthermore, topical formulations using Schisandrin B and (−)Schisandrin B have been clinically tested on human subjects with remarkable anti-aging results.

Schisandrin B and (−)Schisandrin B are the key compounds in Glissandrin™, an active ingredient in anti-aging skincare consisting of natural compounds extracted from the Schisandra berry. This active ingredient has been incorporated into the most advanced anti-aging skincare products, now available from Glissandra™ Skincare Inc.

As the first active ingredient to holistically:

  1. address mitochondrial decay,
  2. increase natural cellular antioxidant capability, and
  3. target other causes of aging,

Glissandrin™ is a breakthrough in the anti-aging skincare industry.

To be continued…

In the next article, the powerful anti-aging properties of Glissandrin™ will be explored in further detail.

For more information

More information on Schisandrin B, (−)Schisandrin B, mitochondrial decay, and theories of aging can be found at these independent websites:


[i] Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention – Systematic Review and Meta-analysis, Bjelakovic et al; Journal of the American Medical Association 2007; 297(8):842-857 (doi:10.1001/jama.297.8.842).

[ii] Vitamins in Aging, Health, and Longevity, David R Thomas; The Division of Geriatric Medicine, Saint Louis University Health Sciences Center, Saint Louis, MO, USA.

[iii] The Hong Kong University of Science and Technology was ranked 35th among research universities worldwide by Times Higher Education in 2009.

From Schisandra berry to Glissandrin

In our previous articles, we reported on advanced scientific research on the Schisandra berry and its incredible health-enhancing features.  But transforming the berry from its natural state into a useful form requires a meticulous extraction process and great care in developing a formulation that enables the berry’s potent properties to be optimally used by the body.

Though the Schisandra berry grows abundantly in parts of Asia, it is not simply the berry in its natural state that produces the greatest health benefits.  The concentrations of the key compounds, (-) Schisandrin B, Schisandrin B, (±)γ-Schisandrin, Schisandrin A, and Schisandrin C, in the natural berries are minute. Additionally, neither compound is soluble in water.  Therefore, crushed berries, berry juice, and Schisandra extracts obtained by ordinary methods contain insignificant amounts of the compounds.

To put this in perspective: the amount of (-) Schisandrin B and Schisandrin A in a single bottle of Glissandra Serum is equivalent to that of a hot tub overflowing with Schisandra berries!  One would have to devote significant time and financial resources to consuming that amount of berries – for a less effective result.

As this relates to skincare, (-) Schisandrin B and Schisandrin A must be in forms that can be absorbed easily by the skin. Furthermore, as natural compounds, optimal dosages must be determined and the intended beneficial effects must be ascertained; this can be done only through clinical studies.

For over 18 years, scientists have been researching and developing Glissandrin, which is procured by a proprietary extraction process that renders (-) Schisandrin B and Schisandrin A in lipid soluble forms, guaranteeing the highest degree of purity (Glissandrins are standardized for consistency in the concentration of Schisandrins), desired level of biological activity, and anti-aging efficacies, while preserving the original chemical identities of the natural compounds.

Despite the over 100 research papers already published by world-class research institutions corroborating the anti-aging and other beneficial properties of these compounds, scientists continue to discover new pharmacological properties of (-) Schisandrin B and Schisandrin A.

A holistic approach to caring for your aging skin

We’ve come to accept the signs of skin aging – wrinkles and expression lines, droopy eyelids, age spots, dark circles, dry skin, enlarged pores, sagging skin, and more (lucky us!) – as an inevitability.  Fortunately, the science of aging has advanced at a remarkable rate in recent years, providing tremendous insight into the causes of and effective solutions for our aging skin.

Numerous studies have identified five major causes of skin aging:

  1. Mitochondrial decay
  2. Inflammation
  3. Oxidative (free-radical induced) damage
  4. Depletion of cellular components, such as collagen and elastin
  5. Adverse external factors

In light of this, it would make sense that your skincare regimen be equipped to combat all causes of skin aging – especially the leading cause, mitochondrial decay – through a comprehensive, holistic approach.  Many anti-aging skincare products contain some combination of common ingredients, such as peptides, antioxidants, and hyaluronic acid, but they don’t stand up to all causes of skin aging simultaneously.  Neglecting even one cause renders the entire approach significantly less effective.  You wouldn’t go into battle with a hole in your armor, would you?

We understand that the condition of our skin as we age, whether we retain our young and healthy look, is influenced in part by genetics and also by environmental factors, which is fantastic if you’ve been blessed with good genes.  But while you can’t control the former, the good news for everyone is that you can control your exposure to adverse external factors, such as the sun, pollution, smoking and poor nutrition.  Avoiding these, while maintaining a conscientious skincare regimen that addresses all causes of skin aging, are easy steps you can take to control your skin’s aging process.

Nature’s contribution to advanced skincare: the Schisandra berry

By now, you’ve likely heard the growing buzz about the Schisandra berry, which is finally beginning to get the widespread attention it deserves, outside the scientific community. It is not just the next disposable “superberry”; Schisandra has been proven to have a significant, positive effect on aging skin.

The Schisandra berry has long been recognized as one of the 50 fundamental herbs of traditional Chinese medicine, and as the key to maintaining youth and radiance. It is now regarded as a vital adaptogen that helps the body achieve a balanced state and adapt to physical, mental, environmental and other stresses.

The Schisandra berry has exciting qualities and applications relating to its status as an adaptogen. It helps the body’s cells maintain and normalize the optimum conditions for their vital functioning. The Schisandra berry is naturally rich in antioxidants, and research suggests that it acts as an antioxidant-site stimulator. In this role, it has been seen to increase antioxidant activity throughout the body, helping fight free radical damage not only by providing its own antioxidants, but also by helping to stimulate antioxidants already present in the body – unlike other, supposed “superberries”.

So how does this affect our skin as we age?

Aging is a phenomenon that occurs in the body’s cells. Its effects are more apparent on the skin, body’s largest organ, and especially noticeable on the face. Aging brings about the depletion of cellular components (such as collagen, hyaluronic acid, etc.), oxidative damage, and inflammation – causing a loss of elasticity, pigmentation, radiance, and other visible signs of aging.

According to extensive research, Schisandra has been found to be “a safe and effective ingredient for the prevention and treatment of hyperproliferative and inflammatory skin conditions and offers a new concept for personal care cosmetics” (Quirin et al.).

However, concentrations of the key compounds, (-) Schisandrin B and Schisandrin A, in the original berries are minute. Ground Schisandra berries, berry juice, or Schisandra extracts collected by ordinary methods contain insignificant amounts of the potent compounds, thereby limiting the benefits to the skin. It is only through a proprietary extraction process that the anti-aging properties of the Schisandra berry can be absorbed by the skin.