Aging is one of the hottest topics today among men and women, young and old. As we forever chase the fountain of youth, it’s not surprising that we all want to know how to prepare ourselves for the battle ahead. One of … Continue reading
VANCOUVER, CANADA (April 16, 2012) – Glissandra Skincare, a product-driven MLM company with a strong international presence, invites its valued independent distributors and friends to celebrate the women who gave them life with these exclusive, limited-time offers.
Until Mother’s Day (May 13, 2012), active distributors who purchase one complete set of Glissandra’s 3-step skincare system (Glissandra Serum, Face Cream, and Eye Cream) will receive a special, one-time Mother’s Day bonus of 68 Incentive Dollars (IND), credited automatically to the purchasing distributor’s account. IND may be redeemed on eligible future purchases of Glissandra products.
In the same time period, new distributors will enjoy two special offers: 1) a reduced membership fee of just $1, and 2) the Mother’s Day Bonus of 68 IND, credited automatically to the purchasing distributor’s account, when they purchase the Quality Enroller Bonus package (Glissandra Serum, Face Cream, and Eye Cream) upon registration. The membership fee is regularly priced at US$30.
Glissandra Skincare always welcomes new distributors to join its growing team. Interested parties are encouraged to visit the company’s website, http://glissandra.com, for more information on this exciting opportunity.
About Glissandra™ Skincare Inc.
Glissandra™ Skincare Inc. is a network marketing company (also known as multi-level marketing, MLM, direct sales, or community commerce) dedicated to providing effective anti-aging skincare through its holistic approach to skin health. Glissandra’s comprehensive skincare system is the result of over 20 years of research and development at the Hong Kong University of Science and Technology, led by Professor Robert Ko, PhD (University of British Columbia). Over 100 research papers have been published on its proprietary key ingredient, Glissandrin™, a suite of natural compounds extracted from the Schisandra berry. In-vivo and in-vitro studies have proven the ability of Glissandrin™ to address mitochondrial decay, the leading cause of aging, and to enhance the cell’s natural ability to fight oxidative damage (http://glissandra.com).
Half a century ago, a German dermatologist concocted an ointment to treat skin that had undergone harsh cosmetic procedures. Dubbed a “blemish balm” or “BB cream”, the creation gained popularity in Asia, with Korean customers leading the way.
Now, BB creams are all the rage in North American, as major brands launch their own version of the multi-tasking hybrid that aims to bridge the gap between skincare and cosmetics.
It’s hard to believe that any product can replace all the steps in your skincare routine without compromising the effectiveness of each. But when we compare the claims made by BB creams with the proven benefits of the Glissandra Serum, it’s clear that Glissandra has been developing its own interpretation of a BB cream in the decades of research behind its potent Serum.
Glissandra Serum is powered by Glissandrin™, a patented suite of health-promoting compounds extracted from the Schisandra berry. This youth-preserving fruit has been the foundation of thousands of years of traditional Chinese medicine, and its potent extracts are now the subject of intensive study in Western medicine, as scientists search for a sustainable way to maintain the function of the body’s organs as we age.
Let’s take a look at how the Glissandra Serum, with Glissandrin at its core, stacks up against BB creams.
|BB Cream||Glissandra Serum|
|Smooth skin after cosmetic treatments||
|Moisturize the skin||
|Protect from the sun||
|Even skin tone and hide blemishes||
Healthy, young-looking skin is now within reach; we simply need to shift the focus from covering skin to creating naturally beautiful skin at the cellular level; from fighting symptoms to addressing the root cause of skin issues, mitochondrial decay. Before jumping on the BB cream bandwagon, consider how you can achieve real, sustainable results from products that put skin health first.
This is Part 3 of a 3-part series on the quest by scientists to find effective ways to fight skin aging. In our previous article, entitled “What have scientists found to fight the leading cause of skin aging – mitochondrial decay?”, we discussed how Schisandrin B and (−)Schisandrin B have been proven to be successful in that regard, dramatically improving the appearance of aging skin.
A study related to this was recently published in the Journal of Cosmetic Dermatology, the official publication of the International Academy of Cosmetic Dermatology. “Mitochondria: a new focus as an anti-aging target in skin care” confirms the important role of mitochondrial function in aging and advocates targeting mitochondria in the development of new products.
Here, we continue to explore the use of Schisandrin B and (−)Schisandrin B in the revolutionary new ingredient, Glissandrin™, which promises to change the way we approach skin care.
As discussed in previous articles, mitochondrial decay plays a fundamental role in the process of aging. Over time, cells lose the ability to function normally, falling victim to free radicals and the ensuing oxidative stress. The consequences of this appear as the visible signs of skin aging, including wrinkles, fine lines, age spots, loss of suppleness, and a marked deterioration in skin tone.
Glissandrin™ is a suite of natural compounds isolated from the Schisandra berry. Consisting mainly of Schisandrin B and (−)Schisandrin B, Glissandrin™ also comprises (±)γ-Schisandrin, Schisandrin A, and Schisandrin C. Extensive research on Glissandrin™ has confirmed its anti-aging properties on skin cells, most notably on its ability to target the fundamental cause of aging: mitochondrial decay.
A. Mitochondrial decay in skin cells can be reversed by topical application of Glissandrin™
A 3-day application of Glissandrin™ cream (2% and 5%) to skin cells caused a dose-dependent increase in reduced glutathione (GSH) and α-tocopherol (α-Toc) levels in skin mitochondria. Glissandrin™ cream is able to enhance the antioxidant capacity of mitochondria and to reverse mitochondrial decay in aging skin cells.
Cream containing 2% or 5% Glissandrin™ was applied to skin cells on a daily basis for 3 days. The control group was treated with cream containing no Glissandrin™. Skin tissues were isolated and mitochondrial fractions were prepared. Mitochondrial reduced glutathione and α-tocopherol levels were measured. P < 0.05 when compared to the control, using Student’s t-test.
B. Mitochondrial functional capabilities in skin cells can be enhanced by topical application of Glissandrin™
Glissandrin™ also dose-dependently increased mitochondrial ATP (cellular energy) production in human skin cells, indicative of enhancement in mitochondrial functional ability.
Cultured human skin cells were incubated with Glissandrin™ at the indicated concentration for 24 or 48 hours. ATP generation capacity was measured in situ and data were expressed as the percentage of control. P < 0.05 when compared to the control, using Student’s t-test.
C. In-vivo and in-vitro studies have confirmed other properties of Glissandrin™ that are beneficial to the skin :
- Emolliating proliferative skin conditions
- Enhancing the natural antioxidative capabilities in skin cells
- Increasing the expression of cellular heat shock proteins, thereby alerting the skin to adverse external environmental factors
- Suppressing inflammation
- Inhibiting the production of collagenase, an enzyme that destroys collagen
- Protecting skin cells from solar radiation – particularly UV – and repairing skin cells with UV damage
- Reducing the destruction of elastin, a protein in the skin matrix responsible for skin elasticity
- Inhibiting ATR protein kinase activity (cancer prevention)
Glissandrin™ has been clinically tested to be safe for even the most sensitive skin, especially for users who experience adverse reactions to most skincare products.
The desired level of biological availability and the purity of chemical compositions of Glissandrin™ are standardized through a proprietary process developed specifically for its manufacturing. Furthermore, the concentrations of the constituent compounds have been formulated for easy absorption, optimal efficacy, and a luxurious feel when applied to the skin.
The International Academy of Cosmetic Dermatology has spoken, and its message is clear: targeting mitochondrial decay is now the goal of the anti-aging industry. Without understanding and addressing mitochondrial decay, the leading cause of skin aging, most skincare products are ill-equipped to provide the real, sustainable results they promise. Fortunately, Glissandrin™ is available today as the ultimate anti-aging skincare solution.
For More Information
More information on Schisandrin B, (−)Schisandrin B, and mitochondrial decay can be found on these independent websites:
National Institutes of Health (http://www.nih.gov/)
Natural Standard (http://www.naturalstandard.com/)
About Glissandra™ Skincare Inc.
Glissandra™ Skincare Inc. is a network marketing company (also known as multi-level marketing, MLM, or direct sales) dedicated to providing effective anti-aging skincare through its holistic approach to skin health. Glissandra’s comprehensive skincare system is the result of over 20 years of research and development at the Hong Kong University of Science and Technology, led by Dr. Robert Ko. Over 100 research papers have been published on its key proprietary ingredient, Glissandrin™, a suite of natural compounds extracted from the Schisandra berry. In-vivo and in-vitro studies have proven the ability of Glissandrin™ to address mitochondrial decay, the leading cause of aging, and to enhance the cell’s natural ability to fight oxidative damage. (http://glissandra.com).
“Mitochondria: a new focus as an anti-aging target in skin care”; Menon et al, Global R&D, ISP Corporation, New Jersey, USA; Journal of Cosmetic Dermatology 2010, Wiley Periodicals Inc.
“Composition and Biological Activity of Different Extract from Schisandra sphenanthera and Schisandra chinensis”; Huyke, et al., Department of Dermatology, University Medical Centre, Freiburg, Germany; Planta Medica 2007.
“Schisandrin B-induced increase in cellular glutathione level and protection against oxidant injury are mediated by the enhancement of glutathione synthesis and regeneration in AML12 and H9c2 cells”, Ko et al., Biofactors 2006; 26: 221-230.
“Hepatoprotective mechanism of Schisandrin B: Role of mitochondrial glutathione antioxidant status and heat shock proteins”, Ko et al., Free Radic. Biol. Med. 2003; 35: 368-380.
“Composition and Biological Activity of Different Extracts from Schisandra sphenanthera and Schisandra chinensis”, Huyke et al., Department of Dermatology, University Medical Center, Freiberg, Germany, Planta Med 2007 73: 1116-1126.
“Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts”; Ko et al.; Department of Biochemistry, the Hong Kong University of Science and Technology; Fitoterapia 82 (2011) 682-691.
“Inhibition of ATR protein kinase activity by Schisandrin B in DNA damage response”, H. Nishida et al., Department of Applied Life Science, Niigata University of Pharmacy and Applied Life Sciences; Nucleic Acids Research 2009, Vol. 37, No. 17.
This is Part 1 of a 3-part series on the quest by scientists to find effective ways to fight skin aging. By understanding the leading cause of aging, mitochondrial decay, we can develop comprehensive solutions for long-term skin health.
Theories of aging
Aging is a consequence of changes that are harmful, progressive, and thus far irreversible in most living organisms, including humans. Age-associated damage occurs to biomolecules, cells, and organs. Diseases such as arthritis, osteoporosis, heart diseases, cancer, Parkinson’s disease, and Alzheimer’s disease occur more frequently with old age.
The biochemical mechanism of aging has long been an area of intensive research, and a number of theories of aging have been proposed, including the neuro-endocrine theory, which links aging to hormonal changes; immunological theory, which attributes aging to immune system dysfunction; telomerase theory, which relates to the shortening of chromosomes during cell division; and oxidative stress theory, which refers to free radical damage to cells.
Among these theories, it is reasonable to distinguish those that attempt to establish primary causes of aging from those that are secondary. For example, the telomerase theory may be secondary since the decrease in telomerase activity can be caused by the increase in cellular oxidative stress.
In gerontology, the study of aging, oxidative stress is increasingly recognized as the primary cause of aging.
The role of mitochondrial decay in aging
If oxidative stress is indeed the primary factor in skin aging, it is important to understand its roots. Scientists now believe that oxidative stress may be caused by mitochondrial decay. Mitochondria, the chief producers of both energy and oxidants inside the cell, play a critical role in the process of aging.
As energy producers, mitochondria convert unusable forms of energy into a usable chemical form known as adenosine triphosphate (ATP), which is required for all vital cellular chemical reactions throughout the body. During the metabolic cycle of ATP production, oxidants are released from the mitochondria as harmful by-products that can damage important biomolecules, such as DNA, lipids, and proteins. At the same time, the mitochondria themselves are also victims of this metabolic cycle of ATP production as they are highly susceptible to damage by the oxidants thus released.
Over time, largely due to cumulated damage by the oxidants, the functional capabilities of mitochondria deteriorate; the production of ATP declines; and the release of oxidants increases. The latter inflicts greater damage to the mitochondria, which in turn results in accelerated oxidant production. This is the vicious cycle of mitochondrial decay. If left unchecked, mitochondrial decay leads to cumulative damage in cellular biomolecules, resulting in a host of age-related diseases.
Effects of mitochondrial decay on the skin
The skin is the body’s largest organ. The consequence of cumulative damage in skin cell biomolecules is a corresponding increase in the depletion of important extracellular components, such as collagen, elastin, and hyaluronic acid, among others. The loss of these significant components is manifested in the appearance of wrinkles, fine lines, droopiness, pigmentation, puffiness, skin inelasticity, enlarged pores, dryness, and a dull skin tone.
An increasing amount of scientific evidence confirms that mitochondrial decay is the fundamental cause of aging; therefore, scientists are endeavoring to find remedies to reverse the declining functional capabilities of mitochondria due to aging. In Parts 2 and 3 of this series, we will explore what scientists have accomplished in this direction.
More information on mitochondrial decay and theories of aging can be found at these independent websites: