五月是皮膚癌關注月!

皮膚癌是美國最普遍的癌症啊,你知道嗎?每年單單是在美國,便有超過 350 萬宗確診皮膚癌個案。據現時統計所指,每 5 名美國人之中便有 1 位會患上皮膚癌。

Glissandra 花了超過 20 年時間,致力硏究及發展我們的先進抗衰老產品。這段時間以來,肌膚的健康一直是我們優先重視的。五味子乙素這一天然複合物,就是我們主要成份的基礎。科學證明,它能幫助保護皮膚細胞免受有害紫外線的傷害。請按此處了解更多關於五味子乙素。

及早發現患上皮膚癌是提高存活率的關鍵。而教育對於幫助我們發現和治療還是在可治癒狀態下的皮膚癌這一點之上,實在非常重要。這正是我們想與大家分享一些關於皮膚癌的關鍵事實的原因,使我們可以共同對抗這致命疾病。

皮膚癌是什麼?

皮膚癌是皮膚細胞出現不正常生長。

皮膚癌可以分為兩類:黑色素瘤及非黑色素瘤。黑色素瘤便是最致命的一類。另外,你可能也聽説過基底細胞癌及鱗狀細胞癌,它們則是最普遍的非黑色素瘤。

是什麼引致皮膚癌?

當皮膚細胞的DNA損壞而身體未能把損壞修復好的話,就是皮膚癌了。暴露於太陽光下是皮膚癌的首要原因。不幸的是,如果你有皮膚癌的家族病史,你自行發病的好能性會比較高,但你仍然能以一些簡單的選擇來保護自己。

怎樣才能好好保護皮膚?

  • 避免使用日曬床 任何人都沒有正當理由把自己暴露於這樣的危險之中。 若你要堅持擁有古銅膚色,建議使用有害性較小的替代品,例如免曬類美黑產品或美黑噴霧。 (請務必遵照指示使用,因為這些產品也有自己的風險。) 最佳選擇當然應該是你與生俱來的自然肌膚!
  • 避開太陽最猛烈的時間 (上午10時至下午4時) — 如果你必須留在戶外,請算擇陰涼之處。
  • 選擇能保護你皮膚、頭髮及眼睛的裝束 長袖衫,長褲,闊邊帽和太陽鏡在保護你的同時也能讓你變得更時髦。
  • 使用耐水性的防曬品 能有效阻擋紫外線 UVA 和 UVB。 請緊記在曬太陽前至少 20 分鐘塗抹,而且隨後每 2 小時也要再重新塗抹。即使是陰天也須要防曬的!
  • 諮詢你的醫生或藥劑師 你服用中的藥物有可能使你的皮膚更容易受到陽光的傷害。

如何檢查自己的皮膚?

由於損傷是發生在皮膚表面上,所以一般在早期階段已能被發現。定期進行自我檢查是非常重要的。

一個簡單的方法是利用「黑色素瘤的 ABCDE」來記下要尋找什麼:

  • A: Asymmetry 不對稱
  • B: Border 邊緣
  • C: Colour 顔色
  • D: Diameter 直徑
  • E: Evolving 變化

如果你注意到你的痣或色素斑展示出以上的一個或多個跡象,請即聯絡你的皮膚科醫生。即使結果是虛驚一場也不用覺得不好意思。以防萬一的心態可能正好保住了你的性命。

了解更多

美國皮膚科醫學會最近發起了一項新的公眾認識倡議。其 SPOT 皮膚癌運動的口號「預防!檢查!活著!」鼓勵人們積極的照顧自己皮膚健康。我們鼓勵所有會員和朋友瀏覽美國皮膚科醫學會網頁去了解更多關於皮膚的知識。

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Are we ever too young to take care of our skin?

Aging is one of the hottest topics today among men and women, young and old. As we forever chase the fountain of youth, it’s not surprising that we all want to know how to prepare ourselves for the battle ahead. One of … Continue reading

Update re: a letter from a customer and fan

A couple of weeks ago, we shared a letter from a customer who found great relief from acute sunburns on his scalp after using Glissandra Serum. Pino has since written again to share a lesson he learned about staying vigilant with sun protection.

When I sent you my testimonial a while ago, I forgot to mention that after healing my scalp I became a little complacent and stopped using the Serum for some time as I kept procrastinating ordering a new supply. When I saw my scalp starting to deteriorate again, I resumed the Serum application and gradually it restored my scalp skin as before. I don’t intend to have that happen again…

As we move into the spring and summer months, with long days of glorious sunshine, it is important to continue using the proper products to protect our skin from harmful UV rays.

Glutathione: The Experts Weigh In

In a recent post, we learned that Schisandrin B stimulates the production of glutathione (GSH), the body’s most potent natural antioxidant. Using anti-aging skincare products that contain Schisandrin B will effectively and drastically reduce the unsightly physical manifestations of skin aging, such as wrinkles, age spots, droopy eyelids, and sagging neck skin.

Like no man is an island, no organ of the body functions entirely independently of the others. Our cells work in harmony to create and sustain life. Though we have discussed the importance of glutathione in skin health, it is important to consider the wider-ranging implications of glutathione for our overall well-being.

Expert opinions

Here’s what some of the experts are saying about the role of glutathione in health:

“No other antioxidant is as important to overall health as glutathione. It is the regenerator of immune cells and the most valuable detoxifying agent in the body. Low levels are associated with early aging and even death.”

– Lorna R. Vanderhaeghe and Patrick J.D. Bouic, Ph.D., The Immune System Cure

“Raised glutathione levels fight the oxidation of circulating fats in the bloodstream, including cholesterol, retarding the process of plaque formation in the arteries – the underlying cause for most heart disease and stroke.”

– Nutrition Reviews 54: 1-30, 1996

“It is well known that aging is accompanied by a precipitous fall in GSH levels. Lower GSH levels are implicated in many diseases associated with aging, including cataracts, Alzheimer’s disease, Parkinson’s, atherosclerosis and others.”

– Journal of Clinical Epidemiology 47: 1021-26, 1994

The future of healthy aging

Scientists around the world have been pursuing progressively more advanced research on glutathione and Schisandrin B. We may not be able to stop the clock, but what we already know about these compounds demonstrates their significance in the campaign for healthy aging, starting with the body’s largest organ: our skin.

References

Quirin, Dr. K. W. et al. Supercritical Schisandra Extracts – a New Concept for Personal Care Cosmetics. Cosmetic Science Technology, 2008.

Gutman, Dr. Jimmy. GSH Your Body’s Most Powerful Protector GLUTATHIONE. Montreal: Kudo.ca Communications, 2002. Print.

Somersall, Dr. Allan C. and Dr. Gustavo Bounous. Breakthrough in Cell-Defense. USA: GOLDENeight Publishing, 1999. Print.

Vanderhaeghe, Lorna R. and Patrick J.D. Bouic, Ph.D. The Immune System Cure. New York: Kensington, 2002. Print.

Glissandrin™: The Ultimate Anti-Aging Skincare Ingredient

This is Part 3 of a 3-part series on the quest by scientists to find effective ways to fight skin aging. In our previous article, entitled “What have scientists found to fight the leading cause of skin aging – mitochondrial decay?”, we discussed how Schisandrin B and (−)Schisandrin B have been proven to be successful in that regard, dramatically improving the appearance of aging skin.

A study related to this was recently published in the Journal of Cosmetic Dermatology, the official publication of the International Academy of Cosmetic Dermatology. “Mitochondria: a new focus as an anti-aging target in skin care” confirms the important role of mitochondrial function in aging and advocates targeting mitochondria in the development of new products.

Here, we continue to explore the use of Schisandrin B and (−)Schisandrin B in the revolutionary new ingredient, Glissandrin™, which promises to change the way we approach skin care.

As discussed in previous articles, mitochondrial decay plays a fundamental role in the process of aging. Over time, cells lose the ability to function normally, falling victim to free radicals and the ensuing oxidative stress. The consequences of this appear as the visible signs of skin aging, including wrinkles, fine lines, age spots, loss of suppleness, and a marked deterioration in skin tone.

Glissandrin™

Glissandrin™ is a suite of natural compounds isolated from the Schisandra berry. Consisting mainly of Schisandrin B and (−)Schisandrin B, Glissandrin™ also comprises (±)γ-Schisandrin, Schisandrin A, and Schisandrin C. Extensive research on Glissandrin™ has confirmed its anti-aging properties on skin cells, most notably on its ability to target the fundamental cause of aging: mitochondrial decay.

Research Findings

A. Mitochondrial decay in skin cells can be reversed by topical application of Glissandrin™

A 3-day application of Glissandrin™ cream (2% and 5%) to skin cells caused a dose-dependent increase in reduced glutathione (GSH) and α-tocopherol (α-Toc) levels in skin mitochondria. Glissandrin™ cream is able to enhance the antioxidant capacity of mitochondria and to reverse mitochondrial decay in aging skin cells.

Figure 1: Glissandrin™ enhances mitochondrial antioxidant capacity in the skin

Cream containing 2% or 5% Glissandrin™ was applied to skin cells on a daily basis for 3 days. The control group was treated with cream containing no Glissandrin™. Skin tissues were isolated and mitochondrial fractions were prepared. Mitochondrial reduced glutathione and α-tocopherol levels were measured. P < 0.05 when compared to the control, using Student’s t-test.

B. Mitochondrial functional capabilities in skin cells can be enhanced by topical application of Glissandrin™

Glissandrin™ also dose-dependently increased mitochondrial ATP (cellular energy) production in human skin cells, indicative of enhancement in mitochondrial functional ability.

Figure 2: Glissandrin™ enhances the mitochondrial functional ability in human skin cells

Cultured human skin cells were incubated with Glissandrin™ at the indicated concentration for 24 or 48 hours. ATP generation capacity was measured in situ and data were expressed as the percentage of control. P < 0.05 when compared to the control, using Student’s t-test.

C. In-vivo and in-vitro studies have confirmed other properties of Glissandrin™ that are beneficial to the skin :

  • Emolliating proliferative skin conditions
  • Enhancing the natural antioxidative capabilities in skin cells
  • Increasing the expression of cellular heat shock proteins, thereby alerting the skin to adverse external environmental factors
  • Suppressing inflammation
  • Inhibiting the production of collagenase, an enzyme that destroys collagen
  • Protecting skin cells from solar radiation – particularly UV – and repairing skin cells with UV damage
  • Reducing the destruction of elastin, a protein in the skin matrix responsible for skin elasticity
  • Inhibiting ATR protein kinase activity (cancer prevention)

Glissandrin™ has been clinically tested to be safe for even the most sensitive skin, especially for users who experience adverse reactions to most skincare products.

The desired level of biological availability and the purity of chemical compositions of Glissandrin™ are standardized through a proprietary process developed specifically for its manufacturing. Furthermore, the concentrations of the constituent compounds have been formulated for easy absorption, optimal efficacy, and a luxurious feel when applied to the skin.

The International Academy of Cosmetic Dermatology has spoken, and its message is clear: targeting mitochondrial decay is now the goal of the anti-aging industry. Without understanding and addressing mitochondrial decay, the leading cause of skin aging, most skincare products are ill-equipped to provide the real, sustainable results they promise. Fortunately, Glissandrin™ is available today as the ultimate anti-aging skincare solution.

For More Information

More information on Schisandrin B, (−)Schisandrin B, and mitochondrial decay can be found on these independent websites:

National Institutes of Health (http://www.nih.gov/)

PubMed (http://www.ncbi.nlm.nih.gov/pubmed/)

Natural Standard (http://www.naturalstandard.com/)

About Glissandra™ Skincare Inc.

Glissandra™ Skincare Inc. is a network marketing company (also known as multi-level marketing, MLM, or direct sales) dedicated to providing effective anti-aging skincare through its holistic approach to skin health. Glissandra’s comprehensive skincare system is the result of over 20 years of research and development at the Hong Kong University of Science and Technology, led by Dr. Robert Ko. Over 100 research papers have been published on its key proprietary ingredient, Glissandrin™, a suite of natural compounds extracted from the Schisandra berry. In-vivo and in-vitro studies have proven the ability of Glissandrin™ to address mitochondrial decay, the leading cause of aging, and to enhance the cell’s natural ability to fight oxidative damage. (http://glissandra.com).

Contact Us

http://www.glissandra.com/

info [at] glissandra [dot] com

1-877-313-7242

References

“Mitochondria: a new focus as an anti-aging target in skin care”; Menon et al, Global R&D, ISP Corporation, New Jersey, USA; Journal of Cosmetic Dermatology 2010, Wiley Periodicals Inc.

“Composition and Biological Activity of Different Extract from Schisandra sphenanthera and Schisandra chinensis”; Huyke, et al., Department of Dermatology, University Medical Centre, Freiburg, Germany; Planta Medica 2007.

“Schisandrin B-induced increase in cellular glutathione level and protection against oxidant injury are mediated by the enhancement of glutathione synthesis and regeneration in AML12 and H9c2 cells”, Ko et al., Biofactors 2006; 26: 221-230.

“Hepatoprotective mechanism of Schisandrin B: Role of mitochondrial glutathione antioxidant status and heat shock proteins”, Ko et al., Free Radic. Biol. Med. 2003; 35: 368-380.

“Composition and Biological Activity of Different Extracts from Schisandra sphenanthera and Schisandra chinensis”, Huyke et al., Department of Dermatology, University Medical Center, Freiberg, Germany, Planta Med 2007 73: 1116-1126.

“Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts”; Ko et al.; Department of Biochemistry, the Hong Kong University of Science and Technology; Fitoterapia 82 (2011) 682-691.

“Inhibition of ATR protein kinase activity by Schisandrin B in DNA damage response”, H. Nishida et al., Department of Applied Life Science, Niigata University of Pharmacy and Applied Life Sciences; Nucleic Acids Research 2009, Vol. 37, No. 17.